Mitochondrial-reticular cytostructure in liver cells

Mitochondrial Regeneration in Liver Cells

Hepatic cells contain, besides well defined organelles--mitochondria, ergastoplasm, and Golgi appara tus-round or ovular structures which recall the "microbodies" described by Rhodin (1) in the brush border kidney cells of the mouse. This work aims to define these organelles, to s tudy their behavior under various experimental conditions and their relation to mitochondria. Ra t liver, either no...

Drug-induced mitochondrial impairment in liver cells

Recently, Laia Tolosa and colleagues from Valencia University have published a study how to identify compounds that cause hepatotoxicity due to compromising mitochondrial functions (Tolosa et al., 2015). The authors used a set of fluorescent probes for imaging: HepG2 cells were loaded with Hoechst 33342 for cell number determination, cell viability was determined with propidium iodid and Mitotr...

Fibroblastic Reticular Cells: Organization

Histopathologic evaluation of mast cells in reticular and erosive oral lichen planus using toluidine blue staining

Introduction: Oral Lichen Planus (OLP) is one of the most common mucocutaneous lesion, and its etiologic factors have not been elucidated yet. OLP has two different clinical forms including reticular and erosive. Mast cells function in non-specific immunology is an etiologic factor involved in the formation of lichen planus. This study aimed at determining the pattern of mast cells presence in ...

"microbodies" and the Problem of Mitochondrial Regeneration in Liver Cells

The cytoplasm of the hepatic cell contains, besides the well known organelles, microbodies, characterized by a single membrane, a finely granular matrix, and average dimensions below those of mitochondria. Microbodies, rare in normal cells, become more numerous in regenerative livers and in various pathological conditions. In these cases, they either evolve towards degenerative forms or else sh...